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O que adianta tomar um antialérgico para aliviar sua alergia, mas que deixa você com sono? É melhor escolher Allegra, os sintomas da alergia* passam e seu dia continua. *Rinite Alérgica e urticária. **Bronfeniramina6, Cetirizina2,3,4,5, Cetotifeno5, Clorferinamina7, Dexclorfeniramina²,5,6,7, Difenidramina5, Ebastina5, Epinastina5, Hidroxizina³,5,6,7, Levocetirizina5, Loratadina2,4,5 Referências: 1. Allegra® (bula do produto). 2. Simons FER et al. Clinical pharmacology of sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol, 2004 Aug 44(8): 890-900. 3. Tashiro, M et al. Central Effects of Fexofenadine and Cetirizine: Measurement of Psychomotor Performance, Subjective Sleepiness, and Brain Histamine H1-Receptor Occupancy Using 11C-Doxepin Positron Emission Tomography. J Clin Pharmacol 2004;44:890-90. 4. Hindmarch I, Shamsi Z, Kimber S. An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. Clin Exp Allergy. 2002;32:133-9. 5. Kawauchi, Hideyuki et al. Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties. International journal of molecular sciences vol. 20,1 213. 8 Jan. 2019. 6. Druce H.M., Thoden W.R., Mure P., Furey S.A., Lockhart E.A., Xie T., Galant S., Prenner B.M., Weinstein S., Ziering R., Brandor M.L. Brompheniramine, Loratadine, and Placebo in Allergic Rhinitis: A Placebo-Controlled Comparative Clinical Trial. J Clin Pharmacol, 38: 382-389: 1998. 7. Devillier P, Roche N, Faisy C. Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine: a comparative review. Clin Pharmacokinet 2008;47:217–30.


O que adianta tomar um antialérgico para aliviar sua alergia, mas que deixa você com sono? É melhor escolher Allegra, os sintomas da alergia* passam e seu dia continua. *Rinite Alérgica e urticária. **Bronfeniramina6, Cetirizina2,3,4,5, Cetotifeno5, Clorferinamina7, Dexclorfeniramina²,5,6,7, Difenidramina5, Ebastina5, Epinastina5, Hidroxizina³,5,6,7, Levocetirizina5, Loratadina2,4,5 Referências: 1. Allegra® (bula do produto). 2. Simons FER et al. Clinical pharmacology of sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol, 2004 Aug 44(8): 890-900. 3. Tashiro, M et al. Central Effects of Fexofenadine and Cetirizine: Measurement of Psychomotor Performance, Subjective Sleepiness, and Brain Histamine H1-Receptor Occupancy Using 11C-Doxepin Positron Emission Tomography. J Clin Pharmacol 2004;44:890-90. 4. Hindmarch I, Shamsi Z, Kimber S. An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. Clin Exp Allergy. 2002;32:133-9. 5. Kawauchi, Hideyuki et al. Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties. International journal of molecular sciences vol. 20,1 213. 8 Jan. 2019. 6. Druce H.M., Thoden W.R., Mure P., Furey S.A., Lockhart E.A., Xie T., Galant S., Prenner B.M., Weinstein S., Ziering R., Brandor M.L. Brompheniramine, Loratadine, and Placebo in Allergic Rhinitis: A Placebo-Controlled Comparative Clinical Trial. J Clin Pharmacol, 38: 382-389: 1998. 7. Devillier P, Roche N, Faisy C. Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine: a comparative review. Clin Pharmacokinet 2008;47:217–30.


O que adianta tomar um antialérgico para aliviar sua alergia, mas que deixa você com sono? É melhor escolher Allegra, os sintomas da alergia* passam e seu dia continua. *Rinite Alérgica e urticária. **Bronfeniramina6, Cetirizina2,3,4,5, Cetotifeno5, Clorferinamina7, Dexclorfeniramina²,5,6,7, Difenidramina5, Ebastina5, Epinastina5, Hidroxizina³,5,6,7, Levocetirizina5, Loratadina2,4,5 Referências: 1. Allegra® (bula do produto). 2. Simons FER et al. Clinical pharmacology of sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol, 2004 Aug 44(8): 890-900. 3. Tashiro, M et al. Central Effects of Fexofenadine and Cetirizine: Measurement of Psychomotor Performance, Subjective Sleepiness, and Brain Histamine H1-Receptor Occupancy Using 11C-Doxepin Positron Emission Tomography. J Clin Pharmacol 2004;44:890-90. 4. Hindmarch I, Shamsi Z, Kimber S. An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. Clin Exp Allergy. 2002;32:133-9. 5. Kawauchi, Hideyuki et al. Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties. International journal of molecular sciences vol. 20,1 213. 8 Jan. 2019. 6. Druce H.M., Thoden W.R., Mure P., Furey S.A., Lockhart E.A., Xie T., Galant S., Prenner B.M., Weinstein S., Ziering R., Brandor M.L. Brompheniramine, Loratadine, and Placebo in Allergic Rhinitis: A Placebo-Controlled Comparative Clinical Trial. J Clin Pharmacol, 38: 382-389: 1998. 7. Devillier P, Roche N, Faisy C. Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine: a comparative review. Clin Pharmacokinet 2008;47:217–30.


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