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Lupus Treatment Option | BENLYSTA (belimumab)
Prescribing Information: http://bit.ly/2PMHiKe IMPORTANT SAFETY INFORMATION Do not receive BENLYSTA if you are allergic to belimumab or to any of the ingredients in BENLYSTA. BENLYSTA can cause serious side effects. Some of these side effects may cause death. It is not known if BENLYSTA causes these serious side effects. Tell your healthcare provider right away if you have any symptoms of infections (such as fever, chills, coughing up mucus, pain or burning with urination, urinating often, or warm, red, or painful skin or sores on your body), heart problems (such as chest discomfort or pain, or shortness of breath), allergic reactions (itching, swelling of the face, lips, mouth, tongue, or throat, trouble breathing, anxiousness, low blood pressure, dizziness or fainting, headache, nausea, or skin rash) or mental health problems (such as thoughts of suicide or dying, trouble sleeping (insomnia), new or worse anxiety or depression, acting on dangerous impulses). Serious allergic reactions can happen on the day of, or in the days after, receiving BENLYSTA and may cause death. Tell your healthcare provider if you: • think you have an infection or have infections that keep coming back. You should not receive BENLYSTA if you have an infection unless your healthcare provider tells you to. • have or have had mental health problems such as depression or thoughts of suicide. • have recently received a vaccination or if you think you may need a vaccination. If you are receiving BENLYSTA, you should not receive live vaccines. • are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. • are allergic to other medicines. • are receiving other biologic medicines, monoclonal antibodies, or IV infusions of cyclophosphamide (CYTOXAN). • have or have had any type of cancer. • have any other medical conditions. • are pregnant or plan to become pregnant. It is not known if BENLYSTA will harm your unborn baby. You should talk to your healthcare provider about whe
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Prescribing Information: http://bit.ly/2PMHiKe IMPORTANT SAFETY INFORMATION Do not receive BENLYSTA if you are allergic to belimumab or to any of the ingredients in BENLYSTA. BENLYSTA can cause serious side effects. Some of these side effects may cause death. It is not known if BENLYSTA causes these serious side effects. Tell your healthcare provider right away if you have any symptoms of infections (such as fever, chills, coughing up mucus, pain or burning with urination, urinating often, or warm, red, or painful skin or sores on your body), heart problems (such as chest discomfort or pain, or shortness of breath), allergic reactions (itching, swelling of the face, lips, mouth, tongue, or throat, trouble breathing, anxiousness, low blood pressure, dizziness or fainting, headache, nausea, or skin rash) or mental health problems (such as thoughts of suicide or dying, trouble sleeping (insomnia), new or worse anxiety or depression, acting on dangerous impulses). Serious allergic reactions can happen on the day of, or in the days after, receiving BENLYSTA and may cause death. Tell your healthcare provider if you: • think you have an infection or have infections that keep coming back. You should not receive BENLYSTA if you have an infection unless your healthcare provider tells you to. • have or have had mental health problems such as depression or thoughts of suicide. • have recently received a vaccination or if you think you may need a vaccination. If you are receiving BENLYSTA, you should not receive live vaccines. • are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. • are allergic to other medicines. • are receiving other biologic medicines, monoclonal antibodies, or IV infusions of cyclophosphamide (CYTOXAN). • have or have had any type of cancer. • have any other medical conditions. • are pregnant or plan to become pregnant. It is not known if BENLYSTA will harm your unborn baby. You should talk to your healthcare provider about whether to pre
First Approved Lupus Treatment Option | BENLYSTA (belimumab)
Prescribing Information: http://bit.ly/2PMHiKe IMPORTANT SAFETY INFORMATION Do not receive BENLYSTA if you are allergic to belimumab or to any of the ingredients in BENLYSTA. BENLYSTA can cause serious side effects. Some of these side effects may cause death. It is not known if BENLYSTA causes these serious side effects. Tell your healthcare provider right away if you have any symptoms of infections (such as fever, chills, coughing up mucus, pain or burning with urination, urinating often, or warm, red, or painful skin or sores on your body), heart problems (such as chest discomfort or pain, or shortness of breath), allergic reactions (itching, swelling of the face, lips, mouth, tongue, or throat, trouble breathing, anxiousness, low blood pressure, dizziness or fainting, headache, nausea, or skin rash) or mental health problems (such as thoughts of suicide or dying, trouble sleeping (insomnia), new or worse anxiety or depression, acting on dangerous impulses). Serious allergic reactions can happen on the day of, or in the days after, receiving BENLYSTA and may cause death. Tell your healthcare provider if you: • think you have an infection or have infections that keep coming back. You should not receive BENLYSTA if you have an infection unless your healthcare provider tells you to. • have or have had mental health problems such as depression or thoughts of suicide. • have recently received a vaccination or if you think you may need a vaccination. If you are receiving BENLYSTA, you should not receive live vaccines. • are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. • are allergic to other medicines. • are receiving other biologic medicines, monoclonal antibodies, or IV infusions of cyclophosphamide (CYTOXAN). • have or have had any type of cancer. • have any other medical conditions. • are pregnant or plan to become pregnant. It is not known if BENLYSTA will harm your unborn baby. You should talk to your healthcare provider about whether to prevent pregnancy while on BENLYSTA. If you choose to prevent pregnancy, you should use an effective method of birth control while receiving BENLYSTA and for at least 4 months after the final dose of BENLYSTA. Tell your healthcare provider right away if you become pregnant during your treatment with BENLYSTA or if you think you may be pregnant. • become pregnant while receiving BENLYSTA. Talk to your healthcare provider about enrolling in the BENLYSTA Pregnancy Registry. You can enroll in this registry by calling 1-877-681-6296. The purpose of this registry is to monitor the health of you and your baby. • are breastfeeding or plan to breastfeed. It is not known if BENLYSTA passes into your breast milk. You and your healthcare provider should talk about whether or not you should receive BENLYSTA and breastfeed. Possible side effects of BENLYSTA Progressive multifocal leukoencephalopathy (PML) is a serious and life-threatening brain infection. PML can result in death or severe disability. Tell your healthcare provider right away if you notice any new or worsening medical problems: memory loss, trouble thinking, dizziness or loss of balance, difficulty talking or walking, or loss of vision. Medicines that affect the immune system, including BENLYSTA, may increase your risk of certain cancers. The most common side effects of BENLYSTA are nausea, diarrhea, fever, stuffy or runny nose and sore throat, cough, trouble sleeping, leg or arm pain, depression, headache, and pain, redness, itching, or swelling at the site of injection (when given subcutaneously). These are not all the possible side effects of BENLYSTA. Call your doctor for medical advice about side effects. APPROVED USE BENLYSTA is a prescription medication used to treat patients with active systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines. Intravenous dosing of BENLYSTA is approved for adults and children aged 5 years and older. Subcutaneous dosing of BENLYSTA is only approved for adult patients. It is not known if BE
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Impact Journals
The cover for issue 68 of Oncotarget features Figure 4, "Gene expression changes to the TME demonstrate sequential development of innate and adaptive immune responses," by Leong, et al. Intratumoral injection of SD-101 induces significant anti-tumor immunity in preclinical and clinical studies, especially when combined with PD-1 blockade. Combination therapy generated CD8+ T cell-dependent immunity leading to rejection of both non-injected and injected tumors and long-term survival, even in very large tumors. Dr. Mary J. Janatpour from Dynavax Technologies, Inc., Emeryville, CA 94608, USA said, "It has long been appreciated by cancer researchers that the phenotypic heterogeneity and progressive evolution of malignant tumors minimize the chance that any agent targeting a single molecular pathway could effectively cure advanced cancer." The authors have previously demonstrated in mouse tumor models that employing the innate immune system to prime a T cell response, in combination with checkpoint blockade, results in deep and durable anti-tumor efficacy. These high response rates were observed in both injected and non-injected tumor lesions and patients with PD-L1 negative tumors, indicating low levels of basal immune inflammation, responded as well as patients with PD-L1 positive tumors. Intratumorally administered SD-101 exerts its priming activity and ultimate orchestration of a systemic anti-tumor T cell response through multiple mechanisms. The production of interferon stimulates tumor cell killing by natural killer cells, with ensuing tumor antigen release, and induces chemokines that attract T cells back to the tumor bed. Low-dose cyclophosphamide decreases Tregs. Additional impacted biological activities have been described, such as: increased interferon production, induction of immunogenic cell death, increases in effector T cells, and increases in functional NK cells, ...likely to be complementary to SD-101 activity by virtue of modulation of the TME. By administering SD-101 locally, rather than systemically, the researchers demonstrate that localized SD-101 injection combined with systemically administered low-dose cyclophosphamide confers an anti-tumor response at non-injected sites. The Janatpour research Team concluded that taken together, the intratumoral SD-101 plus low-dose CY combination may complement existing checkpoint blockade therapies in patients to improve efficacy in the clinic and extend the benefits of immunotherapy to more patients. Full text - https://doi.org/10.18632/oncotarget.27322 Correspondence to - Mary J. Janatpour - mjanatpour@dynavax.com Keywords - TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity About Oncotarget Oncotarget is a weekly, peer-reviewed, open-access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit http://www.oncotarget.com or connect with @Oncotarget Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM
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